Nick Castellanos and Team Miami (FL) competed at Cooperstown Dreams Park during Week 5 in 2004.

Nick first attended and played varsity baseball at American Heritage School (Plantation, FL). Nick helped American Heritage win the Florida state championship his sophomore year (2008). Nick transferred to Archbishop McCarthy High School (Fort Lauderdale, FL) before his junior year (2009). During his senior season (2010), Nick led his team to the Class 4A state with a .542 batting average, 34 runs scored, 41 RBI and 22 stolen bases. He was named Gatorade Player of the Year in 2010 and Class 6A-5A-4A Player of the Year by the Sun-Sentinel.

In addition to his high school team, Nick played in the 2009 Under Armour All-America Game at Wrigley Field, where he scored three runs, had four doubles and three RBI, winning Most Valuable Player honors. Nick played for the 18U United States national baseball team for in the 2009 Pan American Junior Championships, he finished with a .356 BA including six doubles and nine RBI, leading all players with 14 runs scored, as the team won the gold medal. Nick was named to the All-Tournament team. 

Nick committed to attend the University of Miami (Coral Gables, FL) on a baseball scholarship. However, he was the 44th pick of the 2010 Major League Baseball Amateur draft by the Detroit Tigers. After his high school graduation, he made the leap to professional baseball. Climbing through the minors, Nick made his major league start in left field on September 7, 2013. He was moved to starting third baseman during the 2014 season where he continues to play for the Detroit Tigers. Nick remained with the Tigers until he was traded to the Chicago Cubs in 2019 then traded to the Cincinnati Reds before the 2020 season.

During the 2021 MLB season, Nick he was selected to play in the All-Star Game, won the Silver Slugger Award, and was named to the All-MLB Secont Team. At the end of the 2021 season, Nick left the Reds for the Philadelphia Phillies, helping the team reach the 2022 World Series against the Houston Astros.